Research Details

Epithelial tissue injury is common and can develop due to several factors such as infection, inflammation, toxic compounds, or trauma. Poorly managed epithelial including delayed tissue repair, increases vulnerability to pain and further infection, leading to increased morbidity and extended hospital stay. Treatment options include the use of medical creams, which are currently facing challenges due to the growing concern about antimicrobial resistance. Here, we provide evidence of a probiogel infused with metabolites of Lactobacillus paracasei 7060 that can accelerate tissue repair in an animal model and the underlying molecular mechanisms. Tissue repair was phenotypically observed in terms of wound closure, where the probiogel-treated group healed faster compared to the controls and a commercial hydrogel. Histological observation indicated earlier epithelialization in probiotics- treated wounds. Interestingly, the probiogel group showed higher expression of Toll-like receptor 2 (TLR2), highlighting its potential participation in the accelerated tissue repair process. The differential regulation of TLR2 which potentially accelerated tissue repair can be explained through the presence of genes in L. paracasei 7060 that encode proteins associated with immunity, tissue repair, angiogenesis, stress response, and survival. Our work illuminates an approach to improve tissue repair using a probiogel infused with probiotics.