Formulation of dosage forms from standardized non-toxic bioactive extracts from
indigenous plants
Shirley C. Agrupis, Anabelle B. Alejo, Kristian Gay D. Beltran and Maingelline B. Vivit
Status: On-going
Source of Fund: DOST-PCHRD
Duration:
May 15, 2020 to present
This project targets to develop and establish safe, effective, and quality oral and
topical dosage forms from the five plant extracts with promising anti-inflammatory
activity and non-toxic profile.
Anti-inflammatory and Toxicity Profile of Ethanolic Extracts from Indigenous Plants of
Ilocos Norte
Shirley C. Agrupis, Anabelle B. Alejo, Kristian Gay D. Beltran and Maingelline B. Vivit
Status: Completed
Source of Fund: DOST-PCHRD
Duration:
October 15, 2018 to January 15, 2020
This is the first project under the Program “Development of Anti-inflammatory Herbal
Products from Iluko Indigenous Plants”. It was prompted to thoroughly probe unto the
anti-inflammatory potential and toxicity profile of ten (10) indigenous plants
sourced from municipalities of Ilocos Norte. Medium throughput screening was done
through in vitro antiinflammatory assays, in vitro toxicity tests, and cell-based
orthogonal assay.
The potentially active and non-toxic extracts throughout the anti-inflammatory tests
were advanced to the succeeding product development project.
Phytochemical, Toxicologic Profiling and Anti-inflammatory Activity of Indigenous
Medicinal Plants
Zenaida M. Agngarayngay (retired), Menisa A. Antonio, Roque A. Ulep, Karina K. Damo,
Anabelle L. Bernardo and Kristian Gay Dutdut
Status: Completed
Source of Fund: DOST-PCHRD
Duration:
January 2012 to May 2014
This is a pioneering project of the Tuklas Lunas Program. The project was focused on
the qualitative phytochemical analysis; and toxicologic profiling in terms of the
detection of heavy metals and pesticide residues on the 46 indigenous plants in
Ilocos Norte. The anti-inflammatory screening using induced-paw edema on Spague
Dawley rats was limited to 4 plant species selected based on the phytochemical
constituents present.
LC-MS/MS-Based Metabolite Profiling and In Vitro Anticancer Evaluation of the Philippine
Endemic Cinnamomum anacardium Kosterm
Rhian Jaymar D. Ramil and Ma. Danica I. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
January-December 2021
In Vitro Antihypertensive Activity and Gene Expression Analysis of Psychotria
luzoniensis
Ma. Danica I. Ramil and Rhian Jaymar D. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
January-December 2021
Ethno-Medicinal Documentation and Biophysical Characterization of Herbal Plant used by
Traditional Medical Practitioners in the Rural Areas of Ilocos Norte
Maingelline B. Vivit, Erle Stanley G. Damaso, Cecile A. Gaoat, Mae Ann R. Batuyong and
Elpidio P. Cadalzo Jr.
Status: Completed
Source of Fund: MMSU
Duration:
July 2020 to June 2023
The traditional knowledge on the use of medicinal plants and practices are
valuable information that are passed on from generations to generations among
Traditional Medical Practitioners (TMPs). The knowledge is of good contribution
to the national efforts on the drug discovery research and development program.
However, the rapid urbanization and modernization may reduce the preservation of
the traditional knowledge when remained undocumented.
Hence, this project aims to document the ethno-medicinal plants and the
practices utilized by TMPs in the rural areas of Ilocos Norte. After which, the
geographical location of the uncommon medicinal plant will be characterized
based on several biophysical parameters.
Evaluation of the Physico-Chemical Characteristics, In Vitro Biological Activities, and
Safety Assessment of the Endemic Plant Species in Ilocos Norte
Maingelline B. Vivit, Anabelle B. Alejo, Kristian Gay D. Beltran, Mae Ann R. Batuyong
and Cecile A. Gaoat
Status: Completed
Source of Fund: MMSU
Duration:
July 2020 to July 2022
This project is exploratory research on the physico-chemical characteristics,
biological activities and in vivo safety profile of several endemic plants in Ilocos
Norte.
The studies capitalized on the Philippine endemic and locally endemic plants in
Ilocos Norte from the Family Rubiaceae that are distributed within the northern
Cordillera Mountain Ranges covering Kalbario-Patapat Natural Park (KPNP),
Metropolitan Ilocos Norte Watershed Forest Reserve (MINWFR) and Mt. Lammin of
Pagudpud, Adams, Pasuquin and Carasi.
Immunomodulatory Role of Selected Philippine Terrestrial Endemic Plants
Ma. Danica I. Ramil and Rhian Jaymar D. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
March 2019 – December 2020
Immunomodulatory Role of Selected Philippine Terrestrial Endemic Plants
Ma. Danica I. Ramil and Rhian Jaymar D. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
March 2019 – December 2020
Cancer Chemotherapeutic Potentials of Terrestrial Plants Endemic to Ilocos Norte,
GAA-Funded Researchlants
Rhian Jaymar D. Ramil and Ma. Danica I. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
February 2019 – December 2020
A new hexenoic acid glycoside with cytotoxic activity from the leaves of Psychotria
luzoniensis
Rhian Jaymar D. Ramil and Ma. Danica I. Ramil
Status: Completed
Source of Fund: MMSU
Duration:
April 2019- June 2019
Screening and Evaluation of Indigenous Plants for Health and Other Applications
Maingelline B. Vivit, Menisa A. Antonio and Cecil A. Gaoat
Status: Completed
Source of Fund: MMSU
Duration:
2017-2021
Indigenous plants have been utilized primarily as source of food in Ilocos
Norte. These are excellent sources of vitamins, minerals and phytochemicals.
However, food processing is known to affect the phytoconstituents and health
benefits of the vegetables. In this project, the antioxidant and antimicrobial
activity of the raw, boiled, steamed and dried edible parts of eight indigenous
plant species were assessed. The total phenolics (TPC) and flavonoids content
were also analyzed to determine the corresponding effect of these constituents
on the biological activities of the tested plant species.
